MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers

Tamoxifen is effective for treating estrogen receptor-alpha (ER) positive breast cancers. However, few molecular mediators of tamoxifen resistance have been elucidated. Here we describe a previously unidentified gene, MACROD2 that confers tamoxifen resistance and estrogen independent growth. We foun...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Mohseni, Morassa, Cidado, Justin, Croessmann, Sarah, Cravero, Karen, Cimino-Mathews, Ashley, Wong, Hong Yuen, Scharpf, Rob, Zabransky, Daniel J., Abukhdeir, Abde M., Garay, Joseph P., Wang, Grace M., Beaver, Julia A., Cochran, Rory L., Blair, Brian G., Rosen, D. Marc, Erlanger, Bracha, Argani, Pedram, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267353/
https://ncbi.nlm.nih.gov/pubmed/25422431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408650111
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