MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers

Tamoxifen is effective for treating estrogen receptor-alpha (ER) positive breast cancers. However, few molecular mediators of tamoxifen resistance have been elucidated. Here we describe a previously unidentified gene, MACROD2 that confers tamoxifen resistance and estrogen independent growth. We foun...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mohseni, Morassa, Cidado, Justin, Croessmann, Sarah, Cravero, Karen, Cimino-Mathews, Ashley, Wong, Hong Yuen, Scharpf, Rob, Zabransky, Daniel J., Abukhdeir, Abde M., Garay, Joseph P., Wang, Grace M., Beaver, Julia A., Cochran, Rory L., Blair, Brian G., Rosen, D. Marc, Erlanger, Bracha, Argani, Pedram, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267353/
https://ncbi.nlm.nih.gov/pubmed/25422431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408650111
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