Ki-67 is required for maintenance of cancer stem cells but not cell proliferation

Ki-67 expression is correlated with cell proliferation and is a prognostic marker for various cancers; however, its function is unknown. Here we demonstrate that genetic disruption of Ki-67 in human epithelial breast and colon cancer cells depletes the cancer stem cell niche. Ki-67 null cells had a...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Cidado, Justin, Wong, Hong Yuen, Rosen, D. Marc, Cimino-Mathews, Ashley, Garay, Joseph P., Fessler, Abigail G., Rasheed, Zeshaan A., Hicks, Jessica, Cochran, Rory L., Croessmann, Sarah, Zabransky, Daniel J., Mohseni, Morassa, Beaver, Julia A., Chu, David, Cravero, Karen, Christenson, Eric S., Medford, Arielle, Mattox, Austin, De Marzo, Angelo M., Argani, Pedram, Chawla, Ajay, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868756/
https://ncbi.nlm.nih.gov/pubmed/26823390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7057
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