Ki-67 is required for maintenance of cancer stem cells but not cell proliferation

Ki-67 expression is correlated with cell proliferation and is a prognostic marker for various cancers; however, its function is unknown. Here we demonstrate that genetic disruption of Ki-67 in human epithelial breast and colon cancer cells depletes the cancer stem cell niche. Ki-67 null cells had a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cidado, Justin, Wong, Hong Yuen, Rosen, D. Marc, Cimino-Mathews, Ashley, Garay, Joseph P., Fessler, Abigail G., Rasheed, Zeshaan A., Hicks, Jessica, Cochran, Rory L., Croessmann, Sarah, Zabransky, Daniel J., Mohseni, Morassa, Beaver, Julia A., Chu, David, Cravero, Karen, Christenson, Eric S., Medford, Arielle, Mattox, Austin, De Marzo, Angelo M., Argani, Pedram, Chawla, Ajay, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868756/
https://ncbi.nlm.nih.gov/pubmed/26823390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7057
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