Ki-67 is required for maintenance of cancer stem cells but not cell proliferation

Ki-67 expression is correlated with cell proliferation and is a prognostic marker for various cancers; however, its function is unknown. Here we demonstrate that genetic disruption of Ki-67 in human epithelial breast and colon cancer cells depletes the cancer stem cell niche. Ki-67 null cells had a...

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書誌詳細
出版年:Oncotarget
主要な著者: Cidado, Justin, Wong, Hong Yuen, Rosen, D. Marc, Cimino-Mathews, Ashley, Garay, Joseph P., Fessler, Abigail G., Rasheed, Zeshaan A., Hicks, Jessica, Cochran, Rory L., Croessmann, Sarah, Zabransky, Daniel J., Mohseni, Morassa, Beaver, Julia A., Chu, David, Cravero, Karen, Christenson, Eric S., Medford, Arielle, Mattox, Austin, De Marzo, Angelo M., Argani, Pedram, Chawla, Ajay, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2016
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868756/
https://ncbi.nlm.nih.gov/pubmed/26823390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7057
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