A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations

The PIK3CA gene encodes for the p110 alpha isoform of PI3 kinase and is one of the most frequently mutated oncogenes in human cancers. However, the mechanisms by which PIK3CA mutations activate cell signaling are not fully understood. Here we used a phosphoproteomic approach to compare differential...

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Detalhes bibliográficos
Publicado no:Proteomics
Main Authors: Blair, Brian G., Wu, Xinyan, Zahari, Muhammad Saddiq, Mohseni, Morassa, Cidado, Justin, Wong, Hong Yuen, Beaver, Julia A., Cochran, Rory L., Zabransky, Daniel J., Croessmann, Sarah, Chu, David, Toro, Patricia Valda, Cravero, Karen, Pandey, Akhilesh, Park, Ben Ho
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352327/
https://ncbi.nlm.nih.gov/pubmed/25367220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201400342
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