Activating Mutations in PIK3CA Lead to Widespread Modulation of the Tyrosine Phosphoproteome

The human oncogene PIK3CA is frequently mutated in human cancers. Two hotspot mutations in PIK3CA, E545K and H1047R, have been shown to regulate widespread signaling events downstream of AKT, leading to increased cell proliferation, growth, survival, and motility. We used quantitative mass spectrome...

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發表在:J Proteome Res
Main Authors: Zahari, Muhammad Saddiq, Wu, Xinyan, Blair, Brian G., Pinto, Sneha M., Nirujogi, Raja S., Jelinek, Christine A., Malhotra, Radhika, Kim, Min-Sik, Park, Ben Ho, Pandey, Akhilesh
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641567/
https://ncbi.nlm.nih.gov/pubmed/26267517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.5b00302
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