Phosphoproteomic Analysis Identifies Focal Adhesion Kinase 2 (FAK2) as a Potential Therapeutic Target for Tamoxifen Resistance in Breast Cancer

Tamoxifen, an estrogen receptor-α (ER) antagonist, is an important agent for the treatment of breast cancer. However, this therapy is complicated by the fact that a substantial number of patients exhibit either de novo or acquired resistance. To characterize the signaling mechanisms underlying this...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Proteomics
Prif Awduron: Wu, Xinyan, Zahari, Muhammad Saddiq, Renuse, Santosh, Nirujogi, Raja Sekhar, Kim, Min-Sik, Manda, Srikanth S., Stearns, Vered, Gabrielson, Edward, Sukumar, Saraswati, Pandey, Akhilesh
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4638033/
https://ncbi.nlm.nih.gov/pubmed/26330541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.050484
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