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Activating Mutations in PIK3CA Lead to Widespread Modulation of the Tyrosine Phosphoproteome
The human oncogene PIK3CA is frequently mutated in human cancers. Two hotspot mutations in PIK3CA, E545K and H1047R, have been shown to regulate widespread signaling events downstream of AKT, leading to increased cell proliferation, growth, survival, and motility. We used quantitative mass spectrome...
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| Izdano u: | J Proteome Res |
|---|---|
| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4641567/ https://ncbi.nlm.nih.gov/pubmed/26267517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.5b00302 |
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