PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity

BACKGROUND/PURPOSE: The combined contributions of oncogenes and tumor suppressor genes toward carcino-genesis remain poorly understood. Elucidation of cancer gene cooperativity can provide new insights leading to more effective use of therapies. EXPERIMENTAL DESIGN/METHODS: We used somatic cell geno...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res Treat
Main Authors: Croessmann, Sarah, Wong, Hong Yuen, Zabransky, Daniel J., Chu, David, Rosen, D. Marc, Cidado, Justin, Cochran, Rory L., Dalton, W. Brian, Erlanger, Bracha, Cravero, Karen, Button, Berry, Kyker-Snowman, Kelly, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6100768/
https://ncbi.nlm.nih.gov/pubmed/28190247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-017-4147-2
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