NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

The tumor protein 53 (TP53) tumor suppressor gene is the most frequently somatically altered gene in human cancers. Here we show expression of N-Myc down-regulated gene 1 (NDRG1) is induced by p53 during physiologic low proliferative states, and mediates centrosome homeostasis, thus maintaining geno...

Full description

Saved in:
Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Croessmann, Sarah, Wong, Hong Yuen, Zabransky, Daniel J., Chu, David, Mendonca, Janet, Sharma, Anup, Mohseni, Morassa, Rosen, D. Marc, Scharpf, Robert B., Cidado, Justin, Cochran, Rory L., Parsons, Heather A., Dalton, W. Brian, Erlanger, Bracha, Button, Berry, Cravero, Karen, Kyker-Snowman, Kelly, Beaver, Julia A., Kachhap, Sushant, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577188/
https://ncbi.nlm.nih.gov/pubmed/26324937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503683112
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items