NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

The tumor protein 53 (TP53) tumor suppressor gene is the most frequently somatically altered gene in human cancers. Here we show expression of N-Myc down-regulated gene 1 (NDRG1) is induced by p53 during physiologic low proliferative states, and mediates centrosome homeostasis, thus maintaining geno...

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Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Croessmann, Sarah, Wong, Hong Yuen, Zabransky, Daniel J., Chu, David, Mendonca, Janet, Sharma, Anup, Mohseni, Morassa, Rosen, D. Marc, Scharpf, Robert B., Cidado, Justin, Cochran, Rory L., Parsons, Heather A., Dalton, W. Brian, Erlanger, Bracha, Button, Berry, Cravero, Karen, Kyker-Snowman, Kelly, Beaver, Julia A., Kachhap, Sushant, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2015
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577188/
https://ncbi.nlm.nih.gov/pubmed/26324937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503683112
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