NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

The tumor protein 53 (TP53) tumor suppressor gene is the most frequently somatically altered gene in human cancers. Here we show expression of N-Myc down-regulated gene 1 (NDRG1) is induced by p53 during physiologic low proliferative states, and mediates centrosome homeostasis, thus maintaining geno...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Croessmann, Sarah, Wong, Hong Yuen, Zabransky, Daniel J., Chu, David, Mendonca, Janet, Sharma, Anup, Mohseni, Morassa, Rosen, D. Marc, Scharpf, Robert B., Cidado, Justin, Cochran, Rory L., Parsons, Heather A., Dalton, W. Brian, Erlanger, Bracha, Button, Berry, Cravero, Karen, Kyker-Snowman, Kelly, Beaver, Julia A., Kachhap, Sushant, Hurley, Paula J., Lauring, Josh, Park, Ben Ho
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577188/
https://ncbi.nlm.nih.gov/pubmed/26324937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503683112
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