Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

Clinical genetic testing of BRCA1 and BRCA2 is commonly performed to identify specific individuals at risk for breast and ovarian cancers who may benefit from prophylactic therapeutic interventions. Unfortunately, it is evident that deleterious BRCA1 alleles demonstrate variable penetrance and that...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Cochran, Rory L., Cidado, Justin, Kim, Minsoo, Zabransky, Daniel J., Croessmann, Sarah, Chu, David, Wong, Hong Yuen, Beaver, Julia A., Cravero, Karen, Erlanger, Bracha, Parsons, Heather, Heaphy, Christopher M., Meeker, Alan K., Lauring, Josh, Park, Ben Ho
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694828/
https://ncbi.nlm.nih.gov/pubmed/26246475
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