ESR1 mutations in circulating plasma tumor DNA from metastatic breast cancer patients

PURPOSE: Mutations in the estrogen receptor-alpha (ER) gene, ESR1, have been identified in breast cancer metastases after progression on endocrine therapies. Due to limitations of metastatic biopsies, the reported frequency of ESR1 mutations may be underestimated. Here, we show a high frequency of E...

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izdano v:Clin Cancer Res
Main Authors: Chu, David, Paoletti, Costanza, Gersch, Christina, VanDenBerg, Dustin A., Zabransky, Daniel J., Cochran, Rory L., Wong, Hong Yuen, Toro, Patricia Valda, Cidado, Justin, Croessmann, Sarah, Erlanger, Bracha, Cravero, Karen, Kyker-Snowman, Kelly, Button, Berry, Parsons, Heather, Dalton, W. Brian, Gillani, Riaz, Medford, Arielle, Aung, Kimberly, Tokudome, Nahomi, Chinnaiyan, Arul M., Schott, Anne, Robinson, Dan, Jacks, Karen S., Lauring, Josh, Hurley, Paula, Hayes, Daniel F., Rae, James, Park, Ben Ho
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993201/
https://ncbi.nlm.nih.gov/pubmed/26261103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0943
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