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A combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery

The application of RNA interference (RNAi), either in the clinic or laboratory, requires safe and effective delivery methods. Here we develop a combinatorial approach to synthesize a library of delivery vectors based on two lipid-like substrates with known siRNA delivery capabilities. Members of thi...

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Autori principali: Mahon, Kerry P., Love, Kevin T., Whitehead, Kathryn A., Qin, June, Akinc, Akin, Leshchiner, Elizaveta, Leshchiner, Ignaty, Langer, Robert, Anderson, Daniel G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931596/
https://ncbi.nlm.nih.gov/pubmed/20715849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc100041r
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