Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

RNA interference therapeutics afford the potential to silence target gene expression specifically, thereby blocking production of disease-causing proteins. The development of safe and effective systemic small interfering RNA (siRNA) delivery systems is of central importance to the therapeutic applic...

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Main Authors: Akinc, Akin, Goldberg, Michael, Qin, June, Dorkin, J Robert, Gamba-Vitalo, Christina, Maier, Martin, Jayaprakash, K Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Koteliansky, Victor, Röhl, Ingo, Leshchiner, Elizaveta S, Langer, Robert, Anderson, Daniel G
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835134/
https://ncbi.nlm.nih.gov/pubmed/19259063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.36
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