Modulation of thermal stability can enhance the potency of siRNA

During RNA-induced silencing complex (RISC) assembly the guide (or antisense) strand has to separate from its complementary passenger (or sense) strand to generate the active RISC complex. Although this process was found to be facilitated through sense strand cleavage, there is evidence for an alter...

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Autori principali: Addepalli, Haripriya, Meena, Peng, Chang G., Wang, Gang, Fan, Yupeng, Charisse, Klaus, Jayaprakash, K. Narayanannair, Rajeev, Kallanthottathil G., Pandey, Rajendra K., Lavine, Gary, Zhang, Ligang, Jahn-Hofmann, Kerstin, Hadwiger, Philipp, Manoharan, Muthiah, Maier, Martin A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
Soggetti:
Synthetic Biology and Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978349/
https://ncbi.nlm.nih.gov/pubmed/20610434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq568
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