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Modulation of thermal stability can enhance the potency of siRNA
During RNA-induced silencing complex (RISC) assembly the guide (or antisense) strand has to separate from its complementary passenger (or sense) strand to generate the active RISC complex. Although this process was found to be facilitated through sense strand cleavage, there is evidence for an alter...
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| Autors principals: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978349/ https://ncbi.nlm.nih.gov/pubmed/20610434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq568 |
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