Modulation of thermal stability can enhance the potency of siRNA

During RNA-induced silencing complex (RISC) assembly the guide (or antisense) strand has to separate from its complementary passenger (or sense) strand to generate the active RISC complex. Although this process was found to be facilitated through sense strand cleavage, there is evidence for an alter...

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Main Authors: Addepalli, Haripriya, Meena, Peng, Chang G., Wang, Gang, Fan, Yupeng, Charisse, Klaus, Jayaprakash, K. Narayanannair, Rajeev, Kallanthottathil G., Pandey, Rajendra K., Lavine, Gary, Zhang, Ligang, Jahn-Hofmann, Kerstin, Hadwiger, Philipp, Manoharan, Muthiah, Maier, Martin A.
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2010
נושאים:
Synthetic Biology and Chemistry
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978349/
https://ncbi.nlm.nih.gov/pubmed/20610434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq568
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