Modulation of thermal stability can enhance the potency of siRNA

During RNA-induced silencing complex (RISC) assembly the guide (or antisense) strand has to separate from its complementary passenger (or sense) strand to generate the active RISC complex. Although this process was found to be facilitated through sense strand cleavage, there is evidence for an alter...

詳細記述

保存先:
書誌詳細
主要な著者: Addepalli, Haripriya, Meena, Peng, Chang G., Wang, Gang, Fan, Yupeng, Charisse, Klaus, Jayaprakash, K. Narayanannair, Rajeev, Kallanthottathil G., Pandey, Rajendra K., Lavine, Gary, Zhang, Ligang, Jahn-Hofmann, Kerstin, Hadwiger, Philipp, Manoharan, Muthiah, Maier, Martin A.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2010
主題:
Synthetic Biology and Chemistry
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978349/
https://ncbi.nlm.nih.gov/pubmed/20610434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq568
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