Multivalent Cyclic RGD Conjugates for Targeted Delivery of siRNA

We have designed, synthesized and tested conjugates of chemically modified luciferase siRNA (Luc-siRNA) with bi-, tri- and tetravalent cyclic(arginine-glycine-aspartic) peptides (cRGD) that selectively bind to the αvβ3 integrin. The cellular uptake, subcellular distribution and pharmacological effec...

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Bibliografiske detaljer
Main Authors: Alam, Md. Rowshon, Ming, Xin, Fisher, Michael, Lackey, Jeremy, Rajeev, Kallanthottathil G., Manoharan, Muthiah, Juliano, Rudy
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718025/
https://ncbi.nlm.nih.gov/pubmed/21755983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200235q
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