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Multivalent Cyclic RGD Conjugates for Targeted Delivery of siRNA
We have designed, synthesized and tested conjugates of chemically modified luciferase siRNA (Luc-siRNA) with bi-, tri- and tetravalent cyclic(arginine-glycine-aspartic) peptides (cRGD) that selectively bind to the αvβ3 integrin. The cellular uptake, subcellular distribution and pharmacological effec...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3718025/ https://ncbi.nlm.nih.gov/pubmed/21755983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200235q |
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