Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

Significant progress has been made in the advancement of RNAi therapeutics by combining a synthetic triantennary N-acetylgalactosamine ligand targeting the asialoglycoprotein receptor with chemically modified small interfering RNA (siRNA) designs, including the recently described Enhanced Stabilizat...

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Dades bibliogràfiques
Publicat a:Mol Ther
Autors principals: Foster, Donald J., Brown, Christopher R., Shaikh, Sarfraz, Trapp, Casey, Schlegel, Mark K., Qian, Kun, Sehgal, Alfica, Rajeev, Kallanthottathil G., Jadhav, Vasant, Manoharan, Muthiah, Kuchimanchi, Satya, Maier, Martin A., Milstein, Stuart
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2018
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910670/
https://ncbi.nlm.nih.gov/pubmed/29456020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.12.021
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