Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates

For oligonucleotide therapeutics, chemical modifications of the sugar-phosphate backbone are frequently used to confer drug-like properties. Because 2′-deoxy-2′-fluoro (2′-F) nucleotides are not known to occur naturally, their safety profile was assessed when used in revusiran and ALN-TTRSC02, two s...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Nucleic Acids Res
المؤلفون الرئيسيون: Janas, Maja M, Zlatev, Ivan, Liu, Ju, Jiang, Yongfeng, Barros, Scott A, Sutherland, Jessica E, Davis, Wendell P, Liu, Jingxuan, Brown, Christopher R, Liu, Xiumin, Schlegel, Mark K, Blair, Lauren, Zhang, Xuemei, Das, Biplab, Tran, Chris, Aluri, Krishna, Li, Jing, Agarwal, Saket, Indrakanti, Ramesh, Charisse, Klaus, Nair, Jayaprakash, Matsuda, Shigeo, Rajeev, Kallanthottathil G, Zimmermann, Tracy, Sepp-Lorenzino, Laura, Xu, Yuanxin, Akinc, Akin, Fitzgerald, Kevin, Vaishnaw, Akshay K, Smith, Peter F, Manoharan, Muthiah, Jadhav, Vasant, Wu, Jing-Tao, Maier, Martin A
التنسيق: Artigo
اللغة:Inglês
منشور في: Oxford University Press 2019
الموضوعات:
Chemical Biology and Nucleic Acid Chemistry
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468299/
https://ncbi.nlm.nih.gov/pubmed/30820542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz140
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