Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates

For oligonucleotide therapeutics, chemical modifications of the sugar-phosphate backbone are frequently used to confer drug-like properties. Because 2′-deoxy-2′-fluoro (2′-F) nucleotides are not known to occur naturally, their safety profile was assessed when used in revusiran and ALN-TTRSC02, two s...

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Publicat a:Nucleic Acids Res
Autors principals: Janas, Maja M, Zlatev, Ivan, Liu, Ju, Jiang, Yongfeng, Barros, Scott A, Sutherland, Jessica E, Davis, Wendell P, Liu, Jingxuan, Brown, Christopher R, Liu, Xiumin, Schlegel, Mark K, Blair, Lauren, Zhang, Xuemei, Das, Biplab, Tran, Chris, Aluri, Krishna, Li, Jing, Agarwal, Saket, Indrakanti, Ramesh, Charisse, Klaus, Nair, Jayaprakash, Matsuda, Shigeo, Rajeev, Kallanthottathil G, Zimmermann, Tracy, Sepp-Lorenzino, Laura, Xu, Yuanxin, Akinc, Akin, Fitzgerald, Kevin, Vaishnaw, Akshay K, Smith, Peter F, Manoharan, Muthiah, Jadhav, Vasant, Wu, Jing-Tao, Maier, Martin A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Chemical Biology and Nucleic Acid Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468299/
https://ncbi.nlm.nih.gov/pubmed/30820542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz140
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