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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
Small interfering RNAs (siRNAs) conjugated to a trivalent N-acetylgalactosamine (GalNAc) ligand are being evaluated in investigational clinical studies for a variety of indications. The typical development candidate selection process includes evaluation of the most active compounds for toxicity in r...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5818625/ https://ncbi.nlm.nih.gov/pubmed/29459660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02989-4 |
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