The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies

Short interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs) are the most clinically advanced oligonucleotide-based platforms. A number of N-acetylgalactosamine (GalNAc)-conjugated siRNAs (GalNAc-siRNAs), also referred to as RNA interference (RNAi) therapeutics, are currently in various sta...

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Vydáno v:Toxicol Pathol
Hlavní autoři: Janas, Maja M., Harbison, Carole E., Perry, Victoria K., Carito, Brenda, Sutherland, Jessica E., Vaishnaw, Akshay K., Keirstead, Natalie D., Warner, Garvin
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2018
Témata:
Review Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249674/
https://ncbi.nlm.nih.gov/pubmed/30139307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623318792537
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