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Enhanced Intercellular Delivery of cRGD–siRNA Conjugates by an Additional Oligospermine Modification
[Image: see text] Small interfering RNA (siRNA), consisting a 21-mer duplex molecule, is often modified by conjugation with specific ligands to enhance its capacity for tissue-specific delivery. However, these attempts are hampered by the low permeability of negatively charged RNA molecules to enter...
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| Publié dans: | ACS Omega |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical Society
2018
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6072241/ https://ncbi.nlm.nih.gov/pubmed/30087937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00850 |
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