Modulation of thermal stability can enhance the potency of siRNA

During RNA-induced silencing complex (RISC) assembly the guide (or antisense) strand has to separate from its complementary passenger (or sense) strand to generate the active RISC complex. Although this process was found to be facilitated through sense strand cleavage, there is evidence for an alter...

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Библиографические подробности
Главные авторы: Addepalli, Haripriya, Meena, Peng, Chang G., Wang, Gang, Fan, Yupeng, Charisse, Klaus, Jayaprakash, K. Narayanannair, Rajeev, Kallanthottathil G., Pandey, Rajendra K., Lavine, Gary, Zhang, Ligang, Jahn-Hofmann, Kerstin, Hadwiger, Philipp, Manoharan, Muthiah, Maier, Martin A.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2010
Предметы:
Synthetic Biology and Chemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978349/
https://ncbi.nlm.nih.gov/pubmed/20610434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq568
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