A Dose-Response Study of Antibiotic Resistance in Pseudomonas aeruginosa Biofilms

Por Brooun, Alexei, Liu, Songhua, Lewis, Kim
Publicado em 2000

Purification and Ligand Binding of EmrR, a Regulator of a Multidrug Transporter

Por Brooun, Alexei, Tomashek, John J., Lewis, Kim
Publicado em 1999

Sensory Rhodopsin II Transducer HtrII Is Also Responsible for Serine Chemotaxis in the Archaeon Halobacterium salinarum

Por Hou, Shaobin, Brooun, Alexei, Suk Yu, Hyung, Freitas, Tracey, Alam, Maqsudul
Publicado em 1998

An Archaeal Aerotaxis Transducer Combines Subunit I Core Structures of Eukaryotic Cytochrome c Oxidase and Eubacterial Methyl-Accepting Chemotaxis Proteins

Por Brooun, Alexei, Bell, James, Freitas, Tracey, Larsen, Randy W., Alam, Maqsudul
Publicado em 1998

Reviving B-Factors: Retrospective Normalized B-Factor Analysis of c-ros Oncogene 1 Receptor Tyrosine Kinase and Anaplastic Lymphoma Kinase L1196M with Crizotinib and Lorlatinib

Por Johnson, Ted W., Gallego, Rebecca A., Brooun, Alexei, Gehlhaar, Dan, McTigue, Michele
Publicado no ACS Med Chem Lett (2018)

Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design

Por Chen, Ping, Deng, Ya-Li, Bergqvist, Simon, Falk, Matthew D, Liu, Wei, Timofeevski, Sergei, Brooun, Alexei
Publicado no Protein Sci (2014)

The Crystal Structure of Shikimate Dehydrogenase (AroE) Reveals a Unique NADPH Binding Mode

Por Ye, Sheng, von Delft, Frank, Brooun, Alexei, Knuth, Mark W., Swanson, Ronald V., McRee, Duncan E.
Publicado em 2003

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

Por Falk, Matthew D., Liu, Wei, Bolaños, Ben, Unsal-Kacmaz, Keziban, Klippel, Anke, Grant, Stephan, Brooun, Alexei, Timofeevski, Sergei
Publicado em 2014

Homo-dimerization of the PAS-B Domains of Hypoxia-Inducible Factors

Por Zhu, Jing, Martinez-Yamout, Maria, Cardoso, Rosa, Yan, Jiangli, Love, Robert A., Grodsky, Neil, Brooun, Alexei, Dyson, H. Jane
Publicado em 2012

Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

Por Johnson, Ted W., Bolanos, Ben, Brooun, Alexei, Gallego, Rebecca A., Gehlhaar, Dan, Jalaie, Mehran, McTigue, Michele, Timofeevski, Sergei
Publicado no ACS Med Chem Lett (2018)

Three-dimensional Structure of the EphB2 Receptor in Complex with an Antagonistic Peptide Reveals a Novel Mode of Inhibition

Por Chrencik, Jill E., Brooun, Alexei, Recht, Michael I., Nicola, George, Davis, Leila K., Abagyan, Ruben, Widmer, Hans, Pasquale, Elena B., Kuhn, Peter
Publicado no J Biol Chem (2007)

Remedial Strategies in Structural Proteomics: Expression, Purification and Crystallization of the Vav1/Rac1 Complex

Por Brooun, Alexei, Foster, Scott A., Chrencik, Jill E., Chien, Ellen Y.T., Kolatkar, Anand R., Streiff, Markus, Ramage, Paul, Widmer, Hans, Weckbecker, Gisbert, Kuhn, Peter
Publicado em 2006

Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:l-Alanine Ligase (MurC) from Haemophilus influenzae

Por Mol, Clifford D., Brooun, Alexei, Dougan, Douglas R., Hilgers, Mark T., Tari, Leslie W., Wijnands, Robert A., Knuth, Mark W., McRee, Duncan E., Swanson, Ronald V.
Publicado em 2003

Crystal Structure of Nonstructural Protein 10 from the Severe Acute Respiratory Syndrome Coronavirus Reveals a Novel Fold with Two Zinc-Binding Motifs

Por Joseph, Jeremiah S., Saikatendu, Kumar Singh, Subramanian, Vanitha, Neuman, Benjamin W., Brooun, Alexei, Griffith, Mark, Moy, Kin, Yadav, Maneesh K., Velasquez, Jeffrey, Buchmeier, Michael J., Stevens, Raymond C., Kuhn, Peter
Publicado em 2006

Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

Por Long, Yicheng, Bolanos, Ben, Gong, Lihu, Liu, Wei, Goodrich, Karen J, Yang, Xin, Chen, Siming, Gooding, Anne R, Maegley, Karen A, Gajiwala, Ketan S, Brooun, Alexei, Cech, Thomas R, Liu, Xin
Publicado no eLife (2017)

Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein–protein interaction

Por Cardoso, Rosa, Love, Robert, Nilsson, Carol L, Bergqvist, Simon, Nowlin, Dawn, Yan, Jiangli, Liu, Kevin K-C, Zhu, Jing, Chen, Ping, Deng, Ya-Li, Dyson, H Jane, Greig, Michael J, Brooun, Alexei
Publicado em 2012

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Por Brooun, Alexei, Gajiwala, Ketan S., Deng, Ya-Li, Liu, Wei, Bolaños, Ben, Bingham, Patrick, He, You-Ai, Diehl, Wade, Grable, Nicole, Kung, Pei-Pei, Sutton, Scott, Maegley, Karen A., Yu, Xiu, Stewart, Al E.
Publicado no Nat Commun (2016)

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-cell Essential Vav1

Por Chrencik, Jill E., Brooun, Alexei, Zhang, Hui, Mathews, Irimpan I., Hura, Greg L., Foster, Scott A., Perry, J. Jefferson P., Streiff, Markus, Ramage, Paul, Widmer, Hans, Bokoch, Gary M., Tainer, John, Weckbecker, Gisbert, Kuhn, Peter
Publicado em 2008

Structures of the CXCR4 chemokine receptor in complex with small molecule and cyclic peptide antagonists

Por Wu, Beili, Chien, Ellen Y.T., Mol, Clifford D., Fenalti, Gustavo, Liu, Wei, Katritch, Vsevolod, Abagyan, Ruben, Brooun, Alexei, Wells, Peter, Bi, F. Christopher, Hamel, Damon J., Kuhn, Peter, Handel, Tracy M., Cherezov, Vadim, Stevens, Raymond C.
Publicado em 2010

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression

Por Hanson, Michael A., Brooun, Alexei, Baker, Kent A., Jaakola, Veli-Pekka, Roth, Chris, Chien, Ellen, Alexandrov, Alexander, Velasquez, Jeffrey, Davis, Leila, Griffith, Mark, Moy, Kin, Ganser-Pornillos, Barbie, Kuhn, Peter, Ellis, Sam, Yeager, Mark, Stevens, Raymond C.
Publicado em 2007