Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design

von Mathews, Irimpan I
Veröffentlicht 2013

Structural and mechanistic analysis of two prolyl endopeptidases: Role of interdomain dynamics in catalysis and specificity

von Shan, Lu, Mathews, Irimpan I., Khosla, Chaitan
Veröffentlicht 2005

Diffraction study of protein crystals grown in cryoloops and micromounts

von Berger, Michael A., Decker, Johannes H., Mathews, Irimpan I.
Veröffentlicht 2010

Structure and Mechanism of the trans-Acting Acyltransferase from the Disorazole Synthase ()

von Wong, Fong T., Jin, Xi, Mathews, Irimpan I., Cane, David E., Khosla, Chaitan
Veröffentlicht 2011

Electrostatic control of photoisomerization pathways in proteins

von Romei, Matthew G., Lin, Chi-Yun, Mathews, Irimpan I., Boxer, Steven G.
Veröffentlicht in Science (2020)

The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase

von Tang, Yinyan, Kim, Chu-Young, Mathews, Irimpan I., Cane, David E., Khosla, Chaitan
Veröffentlicht 2006

Crystal structure of the glutamate receptor GluA1 amino-terminal domain

von yao, Guorui, Zong, Yinong, Gu, Shenyan, Zhou, Jie, Xu, Huaxi, Mathews, Irimpan I., Jin, Rongsheng
Veröffentlicht 2011

Unified Model for Photophysical and Electro-Optical Properties of Green Fluorescent Proteins

von Lin, Chi-Yun, Romei, Matthew G., Oltrogge, Luke M., Mathews, Irimpan I., Boxer, Steven G.
Veröffentlicht in J Am Chem Soc (2019)

Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction

von Cogan, Dillon P., Li, Xiuyuan, Sevillano, Natalia, Mathews, Irimpan I., Matsui, Tsutomu, Craik, Charles S., Khosla, Chaitan
Veröffentlicht in J Am Chem Soc (2020)

X-ray absorption spectroscopic investigation of the electronic structure differences in solution and crystalline oxyhemoglobin

von Wilson, Samuel A., Green, Evan, Mathews, Irimpan I., Benfatto, Maurizio, Hodgson, Keith O., Hedman, Britt, Sarangi, Ritimukta
Veröffentlicht 2013

Structural Basis of the pH-Dependent Assembly of a Botulinum Neurotoxin Complex

von Matsui, Tsutomu, Gu, Shenyan, Lam, Kwok-ho, Carter, Lester G., Rummel, Andreas, Mathews, Irimpan I., Jin, Rongsheng
Veröffentlicht in J Mol Biol (2014)

Folate binding site of flavin-dependent thymidylate synthase

von Koehn, Eric M., Perissinotti, Laura L., Moghram, Salah, Prabhakar, Arjun, Lesley, Scott A., Mathews, Irimpan I., Kohen, Amnon
Veröffentlicht 2012

An engineered Axl ‘decoy receptor’ effectively silences the Gas6/Axl signaling axis

von Kariolis, Mihalis S., Miao, Yu Rebecca, Jones, Douglas S., Kapur, Shiven, Mathews, Irimpan I., Giaccia, Amato J., Cochran, Jennifer R.
Veröffentlicht in Nat Chem Biol (2014)

Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase

von Li, Xiuyuan, Sevillano, Natalia, Greca, Florencia La, Hsu, Jake, Mathews, Irimpan I., Matsui, Tsutomu, Craik, Charles S., Khosla, Chaitan
Veröffentlicht in Biochemistry (2018)

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX Gene

von Koehn, Eric M., Fleischmann, Todd, Conrad, John A., Palfey, Bruce A., Lesley, Scott A., Mathews, Irimpan I., Kohen, Amnon
Veröffentlicht 2009

Structural and Functional Studies of trans-Encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) Protein Molecule

von Tollefsen, Stig, Hotta, Kinya, Chen, Xi, Simonsen, Bjørg, Swaminathan, Kunchithapadam, Mathews, Irimpan I., Sollid, Ludvig M., Kim, Chu-Young
Veröffentlicht 2012

Cell Fate Regulation Governed by a Repurposed Bacterial Histidine Kinase

von Childers, W. Seth, Xu, Qingping, Mann, Thomas H., Mathews, Irimpan I., Blair, Jimmy A., Deacon, Ashley M., Shapiro, Lucy
Veröffentlicht 2014

Branched signal wiring of an essential bacterial cell-cycle phosphotransfer protein

von Blair, Jimmy A., Xu, Qingping, Childers, W. Seth, Mathews, Irimpan I., Kern, Justin W., Eckart, Michael, Deacon, Ashley M., Shapiro, Lucy
Veröffentlicht 2013

A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl(–)/H(+) transport cycle

von Chavan, Tanmay S, Cheng, Ricky C, Jiang, Tao, Mathews, Irimpan I, Stein, Richard A, Koehl, Antoine, Mchaourab, Hassane S, Tajkhorshid, Emad, Maduke, Merritt
Veröffentlicht in eLife (2020)

Reproducibility of protein x-ray diffuse scattering and potential utility for modeling atomic displacement parameters

von Su, Zhen, Dasgupta, Medhanjali, Poitevin, Frédéric, Mathews, Irimpan I., van den Bedem, Henry, Wall, Michael E., Yoon, Chun Hong, Wilson, Mark A.
Veröffentlicht in Struct Dyn (2021)