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Structural and mechanistic analysis of two prolyl endopeptidases: Role of interdomain dynamics in catalysis and specificity

Prolyl endopeptidases (PEPs) are a unique class of serine proteases with considerable therapeutic potential for the treatment of celiac sprue. The crystal structures of two didomain PEPs have been solved in alternative configurations, thereby providing insights into the mode of action of these enzym...

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Bibliographic Details
Main Authors: Shan, Lu, Mathews, Irimpan I., Khosla, Chaitan
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC553306/
https://ncbi.nlm.nih.gov/pubmed/15738423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408286102
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