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Protein engineering of improved prolyl endopeptidases for celiac sprue therapy

Due to their unique ability to cleave immunotoxic gluten peptides endoproteolytically, prolyl endopeptidases (PEPs) are attractive oral therapeutic candidates for protecting celiac sprue patients from the toxic effects of dietary gluten. Enhancing the activity and stability of PEPs under gastric con...

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Hlavní autoři: Ehren, Jennifer, Govindarajan, Sridhar, Morón, Belén, Minshull, Jeremy, Khosla, Chaitan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583057/
https://ncbi.nlm.nih.gov/pubmed/18836204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzn050
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