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Protein engineering of improved prolyl endopeptidases for celiac sprue therapy

Due to their unique ability to cleave immunotoxic gluten peptides endoproteolytically, prolyl endopeptidases (PEPs) are attractive oral therapeutic candidates for protecting celiac sprue patients from the toxic effects of dietary gluten. Enhancing the activity and stability of PEPs under gastric con...

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Detalles Bibliográficos
Main Authors: Ehren, Jennifer, Govindarajan, Sridhar, Morón, Belén, Minshull, Jeremy, Khosla, Chaitan
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583057/
https://ncbi.nlm.nih.gov/pubmed/18836204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzn050
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