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Protein engineering of improved prolyl endopeptidases for celiac sprue therapy
Due to their unique ability to cleave immunotoxic gluten peptides endoproteolytically, prolyl endopeptidases (PEPs) are attractive oral therapeutic candidates for protecting celiac sprue patients from the toxic effects of dietary gluten. Enhancing the activity and stability of PEPs under gastric con...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2583057/ https://ncbi.nlm.nih.gov/pubmed/18836204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzn050 |
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