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Protein engineering of improved prolyl endopeptidases for celiac sprue therapy

Due to their unique ability to cleave immunotoxic gluten peptides endoproteolytically, prolyl endopeptidases (PEPs) are attractive oral therapeutic candidates for protecting celiac sprue patients from the toxic effects of dietary gluten. Enhancing the activity and stability of PEPs under gastric con...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ehren, Jennifer, Govindarajan, Sridhar, Morón, Belén, Minshull, Jeremy, Khosla, Chaitan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583057/
https://ncbi.nlm.nih.gov/pubmed/18836204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzn050
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