Cargando...

Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction

The 6-deoxyerythronolide B synthase (DEBS) is a prototypical assembly-line polyketide synthase (PKS) that synthesizes the macrocyclic core of the antibiotic erythromycin. Each of its six multidomain modules presumably sample distinct conformations, as biosynthetic intermediates tethered to their acy...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Am Chem Soc
Autores principales: Cogan, Dillon P., Li, Xiuyuan, Sevillano, Natalia, Mathews, Irimpan I., Matsui, Tsutomu, Craik, Charles S., Khosla, Chaitan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484051/
https://ncbi.nlm.nih.gov/pubmed/32786753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c05133
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!