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An engineered Axl ‘decoy receptor’ effectively silences the Gas6/Axl signaling axis
Aberrant signaling through the Axl receptor tyrosine kinase has been associated with a myriad of human diseases, most notably metastatic cancer, identifying Axl and its ligand Gas6 as important therapeutic targets. Using rational and combinatorial approaches, we engineered an Axl ‘decoy receptor’ th...
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| Udgivet i: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4372605/ https://ncbi.nlm.nih.gov/pubmed/25242553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1636 |
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