Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies

The AXL receptor and its activating ligand, growth arrest–specific 6 (GAS6), are important drivers of metastasis and therapeutic resistance in human cancers. Given the critical roles that GAS6 and AXL play in refractory disease, this signaling axis represents an attractive target for therapeutic int...

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Опубликовано в: :J Clin Invest
Главные авторы: Kariolis, Mihalis S., Miao, Yu Rebecca, Diep, Anh, Nash, Shannon E., Olcina, Monica M., Jiang, Dadi, Jones, Douglas S., Kapur, Shiven, Mathews, Irimpan I., Koong, Albert C., Rankin, Erinn B., Cochran, Jennifer R., Giaccia, Amato J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199716/
https://ncbi.nlm.nih.gov/pubmed/27893463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85610
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