Engaging the p53 metabolic brake drives senescence

Por Jiang, Dadi, Attardi, Laura D
Publicado em 2013

Targeting the IRE1α-XBP1 Branch of the Unfolded Protein Response in Human Diseases

Por Jiang, Dadi, Niwa, Maho, Koong, Albert C.
Publicado no Semin Cancer Biol (2015)

A Multimodal Data Analysis Approach for Targeted Drug Discovery Involving Topological Data Analysis (TDA)

Por Alagappan, Muthuraman, Jiang, Dadi, Denko, Nicholas, Koong, Albert C.
Publicado no Adv Exp Med Biol (2016)

Comparison of Effects of p53 Null and Gain-of-Function Mutations on Salivary Tumors in MMTV-Hras Transgenic Mice

Por Jiang, Dadi, Dumur, Catherine I., Massey, H. Davis, Ramakrishnan, Viswanathan, Subler, Mark A., Windle, Jolene J.
Publicado no PLoS One (2015)

Comprehensive Analysis of the Unfolded Protein Response in Breast Cancer Subtypes

Por Jiang, Dadi, Turner, Brandon, Song, Jie, Li, Ruijiang, Diehn, Maximilian, Le, Quynh-Thu, Khatri, Purvesh, Koong, Albert C.
Publicado no JCO Precis Oncol (2017)

Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO–AACR Research Workshop

Por McGee, Heather M., Jiang, Dadi, Soto-Pantoja, David R., Nevler, Avinoam, Giaccia, Amato J., Woodward, Wendy A.
Publicado no Clin Cancer Res (2019)

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages

Por Jiang, Dadi, Brady, Colleen A., Johnson, Thomas M., Lee, Eunice Y., Park, Eunice J., Scott, Matthew P., Attardi, Laura D.
Publicado em 2011

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

Por Kenzelmann Broz, Daniela, Spano Mello, Stephano, Bieging, Kathryn T., Jiang, Dadi, Dusek, Rachel L., Brady, Colleen A., Sidow, Arend, Attardi, Laura D.
Publicado em 2013

Inhibition of IRE1 Results in Decreased Scar Formation

Por Boyko, Tatiana V., Bam, Rakesh, Jiang, Dadi, Wang, Zhen, Bhatia, Namrata, Tran, Misha C., Longaker, Michael T., Koong, Albert C., Yang, George P.
Publicado no Wound Repair Regen (2018)

Loss of the p53/p63 Regulated Desmosomal Protein Perp Promotes Tumorigenesis

Por Beaudry, Veronica G., Jiang, Dadi, Dusek, Rachel L., Park, Eunice J., Knezevich, Stevan, Ridd, Katie, Vogel, Hannes, Bastian, Boris C., Attardi, Laura D.
Publicado em 2010

Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function

Por Jiang, Dadi, LaGory, Edward L., Brož, Daniela Kenzelmann, Bieging, Kathryn T., Brady, Colleen A., Link, Nichole, Abrams, John M., Giaccia, Amato J., Attardi, Laura D.
Publicado no Cell Rep (2015)

Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells

Por Finger, Elizabeth C., Castellini, Laura, Rankin, Erinn B., Vilalta, Marta, Krieg, Adam J., Jiang, Dadi, Banh, Alice, Zundel, Wayne, Powell, Marianne Broome, Giaccia, Amato J.
Publicado no Proc Natl Acad Sci U S A (2015)

A Human Genome-wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation

Por Yang, Zhifen, Zhang, Jing, Jiang, Dadi, Khatri, Purvesh, Solow-Cordero, David E., Toesca, Diego A.S., Koumenis, Constantinos, Denko, Nicholas C., Giaccia, Amato J., Le, Quynh-Thu, Koong, Albert C.
Publicado no Mol Cancer Res (2018)

ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways

Por Feng, Xu, Tubbs, Anthony, Zhang, Chunchao, Tang, Mengfan, Sridharan, Sriram, Wang, Chao, Jiang, Dadi, Su, Dan, Zhang, Huimin, Chen, Zhen, Nie, Litong, Xiong, Yun, Huang, Min, Nussenzweig, André, Chen, Junjie
Publicado no EMBO J (2020)

Chemical Space Mimicry for Drug Discovery

Por Yuan, William, Jiang, Dadi, Nambiar, Dhanya K., Liew, Lydia P., Hay, Michael P., Bloomstein, Joshua, Lu, Peter, Turner, Brandon, Le, Quynh-Thu, Tibshirani, Robert, Khatri, Purvesh, Moloney, Mark G., Koong, Albert C.
Publicado no J Chem Inf Model (2017)

Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Cytotoxic to Human Multiple Myeloma

Por Jiang, Dadi, Tam, Arvin, Alagappan, Muthuraman, Hay, Michael P., Gupta, Aparna, Kozak, Margaret, Solow-Cordero, David E., Lum, Pek Y, Denko, Nicholas, Giaccia, Amato J., Le, Quynh-Thu, Niwa, Maho, Koong, Albert C.
Publicado no Mol Cancer Ther (2016)

Induced tumor heterogeneity reveals factors informing radiation and immunotherapy combinations

Por Aguilera, Todd A., Elghonaimy, Eslam, Shehade, Hussein, Rafat, Marjan, Castellini, Laura, Jiang, Dadi, Kariolis, Mihalis, Koong, Albert C., Le, Quynh-Thu, Ellies, Lesley G., Rankin, Erinn B., Graves, Edward E., Giaccia, Amato J.
Publicado no Clin Cancer Res (2020)

Distinct p53 Transcriptional Programs Dictate Acute DNA Damage Responses and Tumor Suppression

Por Brady, Colleen A., Jiang, Dadi, Mello, Stephano S., Johnson, Thomas M., Jarvis, Lesley A., Kozak, Margaret M., Broz, Daniela Kenzelmann, Basak, Shashwati, Park, Eunice J., McLaughlin, Margaret E., Karnezis, Anthony N., Attardi, Laura D.
Publicado em 2011

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response

Por Jiang, Dadi, Lynch, Connor, Medeiros, Bruno C., Liedtke, Michaela, Bam, Rakesh, Tam, Arvin B., Yang, Zhifen, Alagappan, Muthuraman, Abidi, Parveen, Le, Quynh-Thu, Giaccia, Amato J., Denko, Nicholas C., Niwa, Maho, Koong, Albert C.
Publicado no Sci Rep (2016)

Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies

Por Kariolis, Mihalis S., Miao, Yu Rebecca, Diep, Anh, Nash, Shannon E., Olcina, Monica M., Jiang, Dadi, Jones, Douglas S., Kapur, Shiven, Mathews, Irimpan I., Koong, Albert C., Rankin, Erinn B., Cochran, Jennifer R., Giaccia, Amato J.
Publicado no J Clin Invest (2016)