Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Cytotoxic to Human Multiple Myeloma

Using a luciferase reporter-based high throughput chemical library screen and topological data analysis (TDA), we identified N-acridine-9-yl-N′,N′-dimethylpropane-1,3-diamine (DAPA) as a inhibitor of the IRE1α-XBP1 pathway of the unfolded protein response (UPR). We designed a collection of analogues...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Jiang, Dadi, Tam, Arvin, Alagappan, Muthuraman, Hay, Michael P., Gupta, Aparna, Kozak, Margaret, Solow-Cordero, David E., Lum, Pek Y, Denko, Nicholas, Giaccia, Amato J., Le, Quynh-Thu, Niwa, Maho, Koong, Albert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010920/
https://ncbi.nlm.nih.gov/pubmed/27307600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-1023
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