Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Cytotoxic to Human Multiple Myeloma

Using a luciferase reporter-based high throughput chemical library screen and topological data analysis (TDA), we identified N-acridine-9-yl-N′,N′-dimethylpropane-1,3-diamine (DAPA) as a inhibitor of the IRE1α-XBP1 pathway of the unfolded protein response (UPR). We designed a collection of analogues...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Mol Cancer Ther
Main Authors: Jiang, Dadi, Tam, Arvin, Alagappan, Muthuraman, Hay, Michael P., Gupta, Aparna, Kozak, Margaret, Solow-Cordero, David E., Lum, Pek Y, Denko, Nicholas, Giaccia, Amato J., Le, Quynh-Thu, Niwa, Maho, Koong, Albert C.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010920/
https://ncbi.nlm.nih.gov/pubmed/27307600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-1023
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker