Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response

Activation of the IRE1α-XBP1 branch of the unfolded protein response (UPR) has been implicated in multiple types of human cancers, including multiple myeloma (MM). Through an in silico drug discovery approach based on protein-compound virtual docking, we identified the anthracycline antibiotic doxor...

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Publicado en:Sci Rep
Autores principales: Jiang, Dadi, Lynch, Connor, Medeiros, Bruno C., Liedtke, Michaela, Bam, Rakesh, Tam, Arvin B., Yang, Zhifen, Alagappan, Muthuraman, Abidi, Parveen, Le, Quynh-Thu, Giaccia, Amato J., Denko, Nicholas C., Niwa, Maho, Koong, Albert C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025885/
https://ncbi.nlm.nih.gov/pubmed/27634301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33353
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