Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response

Activation of the IRE1α-XBP1 branch of the unfolded protein response (UPR) has been implicated in multiple types of human cancers, including multiple myeloma (MM). Through an in silico drug discovery approach based on protein-compound virtual docking, we identified the anthracycline antibiotic doxor...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Jiang, Dadi, Lynch, Connor, Medeiros, Bruno C., Liedtke, Michaela, Bam, Rakesh, Tam, Arvin B., Yang, Zhifen, Alagappan, Muthuraman, Abidi, Parveen, Le, Quynh-Thu, Giaccia, Amato J., Denko, Nicholas C., Niwa, Maho, Koong, Albert C.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025885/
https://ncbi.nlm.nih.gov/pubmed/27634301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33353
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы