Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response

Activation of the IRE1α-XBP1 branch of the unfolded protein response (UPR) has been implicated in multiple types of human cancers, including multiple myeloma (MM). Through an in silico drug discovery approach based on protein-compound virtual docking, we identified the anthracycline antibiotic doxor...

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Publicado no:Sci Rep
Main Authors: Jiang, Dadi, Lynch, Connor, Medeiros, Bruno C., Liedtke, Michaela, Bam, Rakesh, Tam, Arvin B., Yang, Zhifen, Alagappan, Muthuraman, Abidi, Parveen, Le, Quynh-Thu, Giaccia, Amato J., Denko, Nicholas C., Niwa, Maho, Koong, Albert C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025885/
https://ncbi.nlm.nih.gov/pubmed/27634301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33353
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