Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response

Activation of the IRE1α-XBP1 branch of the unfolded protein response (UPR) has been implicated in multiple types of human cancers, including multiple myeloma (MM). Through an in silico drug discovery approach based on protein-compound virtual docking, we identified the anthracycline antibiotic doxor...

全面介紹

Na minha lista:
書目詳細資料
發表在:Sci Rep
Main Authors: Jiang, Dadi, Lynch, Connor, Medeiros, Bruno C., Liedtke, Michaela, Bam, Rakesh, Tam, Arvin B., Yang, Zhifen, Alagappan, Muthuraman, Abidi, Parveen, Le, Quynh-Thu, Giaccia, Amato J., Denko, Nicholas C., Niwa, Maho, Koong, Albert C.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
主題:
Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025885/
https://ncbi.nlm.nih.gov/pubmed/27634301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33353
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍