Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells

Scaffold proteins are critical hubs within cells that have the ability to modulate upstream signaling molecules and their downstream effectors to fine-tune biological responses. Although they can serve as focal points for association of signaling molecules and downstream pathways that regulate tumor...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Finger, Elizabeth C., Castellini, Laura, Rankin, Erinn B., Vilalta, Marta, Krieg, Adam J., Jiang, Dadi, Banh, Alice, Zundel, Wayne, Powell, Marianne Broome, Giaccia, Amato J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2015
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394282/
https://ncbi.nlm.nih.gov/pubmed/25792458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418164112
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