ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways

Mechanistic understanding of how ionizing radiation induces type I interferon signaling and how to amplify this signaling module should help to maximize the efficacy of radiotherapy. In the current study, we report that inhibitors of the DNA damage response kinase ATR can significantly potentiate io...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Feng, Xu, Tubbs, Anthony, Zhang, Chunchao, Tang, Mengfan, Sridharan, Sriram, Wang, Chao, Jiang, Dadi, Su, Dan, Zhang, Huimin, Chen, Zhen, Nie, Litong, Xiong, Yun, Huang, Min, Nussenzweig, André, Chen, Junjie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7361286/
https://ncbi.nlm.nih.gov/pubmed/32484965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019104036
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