Distinct p53 Transcriptional Programs Dictate Acute DNA Damage Responses and Tumor Suppression

The molecular basis for p53-mediated tumor suppression remains unclear. Here, to elucidate mechanisms of p53 tumor suppression, we use knock-in mice expressing an allelic series of p53 transcriptional activation mutants. Microarray analysis reveals that one mutant, p53(25,26), is severely compromise...

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Detalhes bibliográficos
Main Authors: Brady, Colleen A., Jiang, Dadi, Mello, Stephano S., Johnson, Thomas M., Jarvis, Lesley A., Kozak, Margaret M., Broz, Daniela Kenzelmann, Basak, Shashwati, Park, Eunice J., McLaughlin, Margaret E., Karnezis, Anthony N., Attardi, Laura D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259909/
https://ncbi.nlm.nih.gov/pubmed/21565614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.035
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