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In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models
p53 is a crucial tumor suppressor, as evidenced by the high propensity for p53 mutation during human cancer development. Already more than a decade ago, p53 knockout mice confirmed that p53 is critical for preventing tumorigenesis. More recently, a host of p53 knock-in mouse strains has been generat...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2915627/ https://ncbi.nlm.nih.gov/pubmed/20097732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp331 |
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