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Illuminating p53 function in cancer with genetically engineered mouse models

The key role of the p53 protein in tumor suppression is highlighted by its frequent mutation in human cancers and by the completely penetrant cancer predisposition of p53 null mice. Beyond providing definitive evidence for the critical function of p53 in tumor suppression, genetically engineered mou...

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Detalhes bibliográficos
Main Authors: Garcia, Patty B., Attardi, Laura D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035469/
https://ncbi.nlm.nih.gov/pubmed/24394915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2013.12.014
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