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Illuminating p53 function in cancer with genetically engineered mouse models
The key role of the p53 protein in tumor suppression is highlighted by its frequent mutation in human cancers and by the completely penetrant cancer predisposition of p53 null mice. Beyond providing definitive evidence for the critical function of p53 in tumor suppression, genetically engineered mou...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4035469/ https://ncbi.nlm.nih.gov/pubmed/24394915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2013.12.014 |
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