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Deciphering p53 Signaling in Tumor Suppression
The p53 transcription factor is mutated in over half of human cancers, and p53-null mice are highly predisposed to cancer, highlighting p53’s essential role in tumor suppression. Studies in mouse models have revealed that p53 cell cycle arrest and apoptosis responses to acute DNA damage signals are...
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| Publicado no: | Curr Opin Cell Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5949255/ https://ncbi.nlm.nih.gov/pubmed/29195118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceb.2017.11.005 |
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