An engineered Axl ‘decoy receptor’ effectively silences the Gas6/Axl signaling axis

Aberrant signaling through the Axl receptor tyrosine kinase has been associated with a myriad of human diseases, most notably metastatic cancer, identifying Axl and its ligand Gas6 as important therapeutic targets. Using rational and combinatorial approaches, we engineered an Axl ‘decoy receptor’ th...

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Bibliographic Details
Published in:Nat Chem Biol
Main Authors: Kariolis, Mihalis S., Miao, Yu Rebecca, Jones, Douglas S., Kapur, Shiven, Mathews, Irimpan I., Giaccia, Amato J., Cochran, Jennifer R.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372605/
https://ncbi.nlm.nih.gov/pubmed/25242553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1636
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