Structural Basis of Guanine Nucleotide Exchange Mediated by the T-cell Essential Vav1

The guanine nucleotide exchange factor (GEF) Vav1 plays an important role in T-cell activation and tumorigenesis. In the GEF superfamily, Vav1 has the ability to interact with multiple families of RhoGTPases. The structure of the Vav1-DH-PH-CRD/Rac1 complex to 2.6 Å resolution reveals a unique intra...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chrencik, Jill E., Brooun, Alexei, Zhang, Hui, Mathews, Irimpan I., Hura, Greg L., Foster, Scott A., Perry, J. Jefferson P., Streiff, Markus, Ramage, Paul, Widmer, Hans, Bokoch, Gary M., Tainer, John, Weckbecker, Gisbert, Kuhn, Peter
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2620086/
https://ncbi.nlm.nih.gov/pubmed/18589439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.024
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