Structural Basis of Guanine Nucleotide Exchange Mediated by the T-cell Essential Vav1

The guanine nucleotide exchange factor (GEF) Vav1 plays an important role in T-cell activation and tumorigenesis. In the GEF superfamily, Vav1 has the ability to interact with multiple families of RhoGTPases. The structure of the Vav1-DH-PH-CRD/Rac1 complex to 2.6 Å resolution reveals a unique intra...

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Main Authors: Chrencik, Jill E., Brooun, Alexei, Zhang, Hui, Mathews, Irimpan I., Hura, Greg L., Foster, Scott A., Perry, J. Jefferson P., Streiff, Markus, Ramage, Paul, Widmer, Hans, Bokoch, Gary M., Tainer, John, Weckbecker, Gisbert, Kuhn, Peter
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2620086/
https://ncbi.nlm.nih.gov/pubmed/18589439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.024
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