The IκBα/NF-κB complex has two hot spots, one at either end of the interface

Por Bergqvist, Simon, Ghosh, Gourisankar, Komives, Elizabeth A.
Publicado em 2008

Two different proteins that compete for binding to thrombin have opposite kinetic and thermodynamic profiles

Por Baerga-Ortiz, Abel, Bergqvist, Simon, Mandell, Jeffrey G., Komives, Elizabeth A.
Publicado em 2004

Biophysical characterization of the free IκBα ankyrin repeat domain in solution

Por Croy, Carrie Hughes, Bergqvist, Simon, Huxford, Tom, Ghosh, Gourisankar, Komives, Elizabeth A.
Publicado em 2004

Kinetic enhancement of NF-κB·DNA dissociation by IκBα

Por Bergqvist, Simon, Alverdi, Vera, Mengel, Benedicte, Hoffmann, Alexander, Ghosh, Gourisankar, Komives, Elizabeth A.
Publicado em 2009

Thermodynamics reveal that helix four in the NLS of NF-κB p65 anchors IκBα, forming a very stable complex

Por Bergqvist, Simon, Croy, Carrie H., Kjaergaard, Magnus, Huxford, Tom, Ghosh, Gourisankar, Komives, Elizabeth A.
Publicado em 2006

MIRG Survey 2011: Snapshot of Rapidly Evolving Label-Free Technologies Used for Characterizing Molecular Interactions

Por Yadav, Satya P., Bergqvist, Simon, Doyle, Michael L., Neubert, Thomas A., Yamniuk, Aaron P.
Publicado em 2012

Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design

Por Chen, Ping, Deng, Ya-Li, Bergqvist, Simon, Falk, Matthew D, Liu, Wei, Timofeevski, Sergei, Brooun, Alexei
Publicado no Protein Sci (2014)

The RelA nuclear localization signal folds upon binding to IκBα

Por Cervantes, Carla F., Bergqvist, Simon, Kjaergaard, Magnus, Kroon, Gerard, Sue, Shih-Che, Dyson, H. Jane, Komives, Elizabeth A.
Publicado em 2010

ABRF–MIRG Benchmark Study: Molecular Interactions in a Three-Component System

Por Yamniuk, Aaron P., Edavettal, Suzanne C., Bergqvist, Simon, Yadav, Satya P., Doyle, Michael L., Calabrese, Kelly, Parsons, James F., Eisenstein, Edward
Publicado em 2012

Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting

Por van Meeteren, Laurens A., Thorikay, Midory, Bergqvist, Simon, Pardali, Evangelia, Gallo Stampino, Corrado, Hu-Lowe, Dana, Goumans, Marie-José, ten Dijke, Peter
Publicado em 2012

Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer

Por Shojaei, Farbod, Scott, Nathan, Kang, Xiaolin, Lappin, Patrick B, Fitzgerald, Amanda A, Karlicek, Shannon, Simmons, Brett H, Wu, Aidong, Lee, Joseph H, Bergqvist, Simon, Kraynov, Eugenia
Publicado em 2012

Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

Por Schwartz, Phillip A., Kuzmic, Petr, Solowiej, James, Bergqvist, Simon, Bolanos, Ben, Almaden, Chau, Nagata, Asako, Ryan, Kevin, Feng, Junli, Dalvie, Deepak, Kath, John C., Xu, Meirong, Wani, Revati, Murray, Brion William
Publicado em 2014

Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein–protein interaction

Por Cardoso, Rosa, Love, Robert, Nilsson, Carol L, Bergqvist, Simon, Nowlin, Dawn, Yan, Jiangli, Liu, Kevin K-C, Zhu, Jing, Chen, Ping, Deng, Ya-Li, Dyson, H Jane, Greig, Michael J, Brooun, Alexei
Publicado em 2012

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-thujaplicinol Bound at the RNase H Active Site

Por Himmel, Daniel M., Maegley, Karen A., Pauly, Tom A., Bauman, Joseph D., Das, Kalyan, Dharia, Chhaya, Clark, Arthur D., Ryan, Kevin, Hickey, Michael J., Love, Robert A., Hughes, Stephen H., Bergqvist, Simon, Arnold, Eddy
Publicado em 2009

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

Por Murray, Brion W., Guo, Chuangxing, Piraino, Joseph, Westwick, John K., Zhang, Cathy, Lamerdin, Jane, Dagostino, Eleanor, Knighton, Daniel, Loi, Cho-Ming, Zager, Michael, Kraynov, Eugenia, Popoff, Ian, Christensen, James G., Martinez, Ricardo, Kephart, Susan E., Marakovits, Joseph, Karlicek, Shannon, Bergqvist, Simon, Smeal, Tod
Publicado em 2010

Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F

Por Shaw, Alice T., Friboulet, Luc, Leshchiner, Ignaty, Gainor, Justin F., Bergqvist, Simon, Brooun, Alexei, Burke, Benjamin J., Deng, Ya-Li, Liu, Wei, Dardaei, Leila, Frias, Rosa L., Schultz, Kate R., Logan, Jennifer, James, Leonard P., Smeal, Tod, Timofeevski, Sergei, Katayama, Ryohei, Iafrate, A. John, Le, Long, McTigue, Michele, Getz, Gad, Johnson, Ted W., Engelman, Jeffrey A.
Publicado no N Engl J Med (2015)

Targeting Activin Receptor-Like Kinase 1 (ALK1) Inhibits Angiogenesis and Tumorigenesis Through a Mechanism of Action Complementary to Anti-VEGF Therapies

Por Hu-Lowe, Dana D., Chen, Enhong, Zhang, Lianglin, Watson, Katherine D., Mancuso, Patrizia, Lappin, Patrick, Wickman, Grant, Chen, Jeffrey H., Wang, Jianying, Jiang, Xin, Amundson, Karin, Simon, Ronald, Erbersdobler, Andreas, Bergqvist, Simon, Feng, Zheng, Swanson, Terri A., Simmons, Brett H., Lippincott, John, Casperson, Gerald F., Levin, Wendy J., Stampino, Corrado Gallo, Shalinsky, David R., Ferrara, Katherine W., Fiedler, Walter, Bertolini, Francesco
Publicado em 2011