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Thermodynamics reveal that helix four in the NLS of NF-κB p65 anchors IκBα, forming a very stable complex
IκBα is an ankyrin repeat protein that inhibits NF-κB transcriptional activity by sequestering NF-κB outside of the nucleus in resting cells. We have characterized the binding thermodynamics and kinetics of the IκBα ankyrin repeat domain to NF-κB(p50/p65) using surface plasmon (SPR) resonance and is...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680085/ https://ncbi.nlm.nih.gov/pubmed/16756995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.05.014 |
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